Set two decades after the original, The Devil Wears Prada 2 follows iconic editor-in-chief Miranda Priestly (Meryl Streep) as she struggles to keep Runway magazine afloat amid declining print media and corporate pressure. To boost the publication's credibility, former assistant Andy Sachs (Anne Hathaway) returns as features editor, where she must navigate modern digital media alongside her former rival Emily Charlton (Emily Blunt), who is now a high-powered luxury brand executive whose advertising clout holds the key to Runway's survival.

As loyal creative director Nigel Kipling (Stanley Tucci) works to preserve the brand's soul, Miranda must balancing threats to her empire with her personal life alongside her new husband (Kenneth Branagh), while dynamic newcomers played by Justin Theroux, Lucy Liu, and Simone Ashley shake up the changing corporate landscape.